China Orthoformate Esters Price - Wholesale Orthoformate Esters Made in China

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Nantong Shengfeng Chemical Co., Ltd. is located in Fengli Town, Nantong City, bordering the Yangtze River to the south and the Yellow Sea to the east. Situated within Shanghai's one-hour economic circle, it enjoys convenient land and water transportation, giving it a significant geographical advantage. The company specializes in producing a series of phosphonates, including phosphonic acid, potassium dihydrogen phosphate, and potassium phosphonate.

Triethyl Orthoform
Item: Content. Chinese Name: Triethyl Orthoformate. English Name: Triethyl orthoformate (Triethoxymethane). Aliases: Triethoxymethane; Ethyl Orthoformate
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Triethyl Orthofor
Item: Content. Chinese Name: Triethyl Orthoformate. English Name: Triethyl orthoformate (Triethoxymethane). Aliases: Triethoxymethane; Ethyl Orthoformate
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Trimethyl Orthofor
Item: Content. Chinese Name: Trimethyl Orthoformate. English Name: Trimethyl orthoformate (Trimethoxymethane). Alias: Trimethoxymethane
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Trimethyl Orthoformate
Item: Content. Chinese Name: Trimethyl Orthoformate. English Name: Trimethyl orthoformate (Trimethoxymethane). Alias: Trimethoxymethane
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Why Choose Us

Rich Experience

We have accumulated 16 years of mature, All products strictly adhere to national standards, ensuring stable and reliable quality.

Sales Market

Our products are exported to South America, North America, Australia, and most parts of Europe, winning unanimous praise from customers both domestically and internationally.

Production Equipment

The production equipment is fully equipped, including 20 reaction kettles, 4 centrifuges, a thermal oil circulating boiler, and a small packaging filling line, which can fully meet the needs of large-scale production and standardized packaging of a series of phosphonate products.

Our Service

We have a professional service team that can provide clients with end-to-end problem solutions. We also support customized formulations with different content specifications and packaging methods based on clients' usage habits and individual needs, maximizing the satisfaction of diverse client requirements.

Overview of Orthoformate Esters

Triethyl orthoformate is an organic compound belonging to the so-called orthoesters, a group of triple esters of hypothetical tricarboxylic acids. The substance is used in various chemical syntheses and, among other things, promotes the completion of esterification reactions by reacting with excess water.

Product Specification

We offers the following product specifications：

Item		Content
Chinese Name		Trimethyl Orthoformate
English Name		Trimethyl orthoformate (Trimethoxymethane)
Alias		Trimethoxymethane
CAS No.		149-73-5
EINECS No.		205-745-7
Molecular Formula		C₄H₁₀O₃
Relative Molecular Mass		106.12
Item	Typical Data		Remarks
Melting Point	−53 ℃		-
Boiling Point	101–102 ℃		lit.
Density	Approx. 0.97 g/cm³ (25 ℃)		-
Flash Point	Approx. 15 ℃ (closed cup)		-
Refractive Index	Approx. 1.379 (20 ℃)		-
Saturated Vapor Pressure	Approx. 23.5 mmHg (20 ℃)		-
Explosion Limits	1.4%–5.1% (v/v)		-
Water Solubility	Slightly soluble		Decomposes upon contact with water
Vapor Density	Approx. 3.67 (air=1)		-
Autoignition Temperature	Approx. 255 ℃		-
Stability	Sensitive to moisture		Recommended to be stored sealed, dry and at low temperature

Physical and Composition

Triethyl orthoformate is a multiple carboxylic acid ester. It represents a hypothetical triple ester of the virtually non-existent orthoformic acid that is actually obtained from the reaction of other compounds such as chloroform or hydrogen cyanide. The molecules of the substance are built around a central carbon atom. In addition to a connected hydrogen atom, this has bonds to three oxygen atoms, which are each connected to an ethyl group and form an ethoxy group with it.

Triethyl orthoformate is in liquid form under normal conditions. The compound is colorless in appearance and has a pleasant, aromatic odor. The substance only reaches its boiling point when heated to 146 °C and withstands severe cooling before congealing to a solid at temperatures below -76 °C. Liquid triethyl orthoformate is lighter than water.

The substance is hygroscopic and attracts moisture, but is only slightly soluble in water. Instead, the compound gradually decomposes on contact with water. In contrast, triethyl orthoformate is readily soluble in many organic solvents such as diethyl ether and ethanol.

Application

Synthesis of Fine Chemicals: It serves as a versatile reagent in organic synthesis, particularly in the preparation of esters and other derivatives, making it invaluable in the pharmaceutical and agrochemical industries.

Protecting Group in Organic Chemistry: This compound is commonly used as a protecting group for alcohols and amines, allowing for selective reactions without interference from functional groups, which is crucial in complex molecule synthesis.

Production of Solvents: Triethyl orthoformate acts as a solvent in various chemical reactions, enhancing the solubility of reactants and improving yields, particularly in laboratory settings.

Formulation of Coatings: Its properties make it suitable for use in the formulation of coatings and adhesives, providing durability and resistance to environmental factors, which is essential in construction and manufacturing.

Research in Material Science: The compound is explored for its potential applications in developing new materials, such as polymers and composites, due to its unique chemical structure and reactivity, paving the way for innovative solutions in various industries.

Precautions

Storage
Store in a sealed package in a cool, dry and well-ventilated warehouse. Maintain the storage conditions as follows: Temperature ≤30℃, relative humidity ≤75%. Keep away from ignition sources, heat, strong acids, strong bases and oxidants. Strictly prohibit mixed storage with food and feed. The shelf life is 6 months.

Transportation
Transport as hazardous goods. Avoid exposure to sunlight, rain and high temperatures. Handle with care during loading and unloading to prevent package damage. The transport vehicle must be equipped with leakage emergency treatment equipment.

Leakage
Isolate the leakage area and wear protective equipment. Cover and collect solid leakage with dry sand; adsorb liquid leakage with vermiculite. Prevent dust from spreading. Wastewater shall be treated by professional institutions.

Exposure
Skin Contact: Rinse the affected area thoroughly with soapy water for 15 minutes.
Eye Contact: Rinse eyes with flowing clean water for 15 minutes and then seek medical attention immediately.
Inhalation: Move the victim to fresh air. Administer oxygen if breathing is difficult.
Ingestion: Rinse the mouth immediately, drink a sufficient amount of warm water to induce vomiting, and seek medical treatment promptly.

Fire
Extinguish the fire with dry powder, carbon dioxide or foam. Do not directly spray water on molten substances. Firefighters must wear full-body fire suits and gas masks.

Package & Delivery

Regular Packaging: 25 kg per fiber drum (lined with plastic bag)
Customized Packaging: 1 kg, 5 kg, 25 kg and other specifications available according to customer requirements

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FAQ

Q: What are orthoformate esters and how are they used in industry?

A: Orthoformate esters are organic compounds derived from formic acid, commonly used as intermediates in pharmaceutical synthesis, agrochemicals, and fine chemicals. They are particularly valuable as formylating agents and protecting group reagents.

Q: What are the most commonly used orthoformate esters?

A: Typical examples include trimethyl orthoformate (TMOF), triethyl orthoformate (TEOF), and triisopropyl orthoformate. Selection depends on reactivity, boiling point, and compatibility with the intended synthesis process.

Q: What are the key applications of orthoformate esters in pharmaceuticals?

A: They are widely used in the synthesis of active pharmaceutical ingredients (APIs), particularly in heterocyclic compound formation, acetalization reactions, and as intermediates in vitamin and antibiotic production.

Q: What purity levels are typically required?

A: Industrial grades are usually ≥98%, while pharmaceutical and electronic applications may require ≥99% purity with strict control over moisture and impurities.

Q: How should orthoformate esters be stored?

A: These compounds should be stored in tightly sealed containers in a cool, dry, and well-ventilated environment. They are moisture-sensitive and can hydrolyze upon exposure to water.

Q: Are orthoformate esters hazardous to handle?

A: They are flammable and may cause irritation to the skin, eyes, and respiratory system. Proper PPE, including gloves and safety goggles, is recommended during handling.

Q: What packaging options are available for bulk supply?

A: Common packaging includes steel drums, HDPE drums, and IBC containers. Customized packaging solutions are often available based on transportation and storage requirements.

Q: What are the transportation considerations for orthoformate esters?

A: Due to their flammability, they are classified as hazardous goods and must be transported in compliance with ADR, IMDG, or DOT regulations, depending on the destination.

Q: How do orthoformate esters function in chemical synthesis?

A: They act as alkylating or formylating agents and are often used to introduce formyl groups or protect functional groups in multi-step organic synthesis.

Q: Can orthoformate esters be customized for specific applications?

A: Yes, manufacturers can adjust purity, moisture content, inhibitor levels, and packaging to meet specific customer requirements, particularly for pharmaceutical or electronic-grade materials.

Q: What quality documentation should suppliers provide?

A: Standard documentation includes Certificate of Analysis (COA), Safety Data Sheet (SDS), Technical Data Sheet (TDS), and in some cases, impurity profiles and GC/HPLC analysis reports.

Q: What is the typical shelf life of orthoformate esters?

A: When stored under recommended conditions, shelf life is typically 12–24 months. Exposure to moisture can significantly reduce stability.

Q: Are orthoformate esters compatible with other solvents and reagents?

A: They are generally compatible with common organic solvents, but reactivity with water, acids, and certain nucleophiles should be carefully managed to avoid unwanted hydrolysis.

Q: What industries commonly use orthoformate esters?

A: Key industries include pharmaceuticals, agrochemicals, coatings, flavors and fragrances, and specialty chemical manufacturing.

Q: What factors influence supplier selection for orthoformate esters?

A: Buyers typically evaluate suppliers based on product consistency, regulatory compliance (e.g., REACH, ISO), supply reliability, technical support, and the ability to meet customized specifications.

We're well-known as one of the most experienced orthoformate esters enterprises in China for 20 years. Please feel free to buy discount orthoformate esters made in China here and get free sample from our factory. For price consultation, contact us.

Triethyl Orthofor, Trimethyl Orthoformate, orthoformate esters